What Is Agmatine?
Agmatine, an organic compound with the molecular formula C5H14N4, plays a role in the biosynthesis of polyamines and is considered a potential neurotransmitter. Its CAS number is 306-60-5, and it is also known as N-(4-aminobutyl) guanidine, among other aliases.
Produced in the brain and stored in synaptic vesicles, agmatine is found naturally in fish and sake, particularly synthesized by koji mold from arginine.
Uses of Agmatine
Agmatine’s physiological effects include muscle strengthening by serving as a precursor to nitric oxide, enhancing mental wellness by increasing NRF2, promoting muscle growth through elevated testosterone levels, and boosting appetite via neuropeptide Y activation. Its potential in treating various conditions like depression, neuralgia, and neurodegenerative diseases, among others, has been supported by preclinical studies, making it a promising ingredient in dietary supplements.
Properties of Agmatine
At room temperature, agmatine is a solid with a molecular weight of 130.195, melting at 102°C and boiling at 281°C. It dissolves in water, has a density of 1.02 g/mL, and features a base dissociation constant (pKb) of 0.52.
Types of Agmatine
Primarily sold as agmatine sulfate, agmatine is available for research and industrial purposes. It is provided in various forms, including salts like agmatine dihydrochloride, and volumes ranging from small to large for laboratory and industrial use.
1. Research and Development
For R&D, agmatine sulfate and other forms are crucial due to their modulatory effects on neurotransmitters, ion channels, and nitric oxide synthesis. These are available in quantities suitable for lab use and can also be part of screening libraries for drug discovery.
2. Industrial Organic Compounds
As an industrial chemical, agmatine sulfate serves as a fine chemical and pharmaceutical intermediate, available in bulk quantities for manufacturing processes.
Other Information on Agmatine
Agmatine Sulfate
Agmatine sulfate, with a molecular weight of 228.27 and a melting point of 234-238°C, appears as a white powder and is identified by the CAS number 2482-00-0.