What Is Dextran Sulfate Sodium?
Dextran sulfate sodium, the sodium salt of the sulfated ester of dextran, is a polymer of glucose. It is also referred to as a glycosaminoglycan. This compound is a mucopolysaccharide characterized by a repeating sugar chain structure, a degree of polymerization of approximately 40 or more, extensive length, and its exceptionally high hydrophilicity.
Common mucopolysaccharides include chondroitin sulfate, a primary component of cartilage, and hyaluronic acid, found in the connective tissue of the skin, umbilical cord, and the eye’s vitreous body. Dextran sulfate sodium does not fall under any specific GHS classification categories, indicating no specific hazard information, and is considered relatively safe.
Uses of Dextran Sulfate Sodium
Dextran sulfate sodium serves as a skin conditioning agent and cosmetic material, offering moisturizing effects and enhancing peripheral blood flow. Additionally, it functions as an inactive dispersant, a binding agent, a treatment for dyslipidemia (hypertriglyceridemia), and an activator of lipoprotein lipase (LPL).
Beyond these applications, it is widely used in the induction of ulcerative colitis in animal models, facilitating research into colon cancer stemming from colon inflammation.
Properties of Dextran Sulfate Sodium
An odorless white to slightly pale yellow crystalline powder, dextran sulfate sodium is identified by CAS No. 9011-18-1. It has a molecular weight range of 36,000-50,000 according to MP Biomedicals, a pH range of 4.5-8.0, and is soluble in water but virtually insoluble in ethanol and acetone. While stable under normal conditions, it should be stored away from high temperatures, direct sunlight, moisture, and strong oxidizing agents.
Other Information on Dextran Sulfate Sodium
1. Handling Methods
Minimize contact with strong oxidizers and maintain closed containers or use local exhaust ventilation. Install safety showers and hand/eye washing facilities near work areas. Protective measures for workers include masks, gloves, goggles, or full-face glasses as necessary, and long-sleeved clothing, adhering to industrial hygiene and safety standards.
Avoid ingestion, inhalation, and dermal exposure during work, ensuring thorough washing and gargling post-handling. Also, prevent contaminated protective gear from leaving the work area.
2. First Aid Measures
For inhalation, seek fresh air and medical advice if symptoms persist. In case of skin contact, wash immediately with soap and plenty of water. If the substance enters the eyes, rinse carefully for several minutes, remove contact lenses if applicable, and seek medical attention if symptoms continue. If ingested, rinse the mouth, avoid giving anything by mouth if unconscious, and consult medical professionals with SDS and handling information at hand.
3. Fire Precautions
In the event of a fire, use water spray, carbon dioxide (CO2), foam, powder, or sand to extinguish. Since no specific fire extinguishing agent is prohibited, select an agent suitable for the surrounding environment. Firefighters should wear appropriate protective equipment, including self-contained breathing apparatus.
4. Storage Methods
Store in a cool, well-ventilated area away from direct sunlight, in tightly sealed glass containers, and distant from strong oxidizers. Dispose of this product through a licensed waste disposal contractor, following relevant regional, national, and local regulations.