What Is Terramycin?
Terramycin, also known as oxytetracycline, is a broad-spectrum antibiotic isolated from the actinomycete Streptomyces rimosus. It belongs to the tetracycline antibiotics class and binds to the 30S ribosomal subunit of bacteria to inhibit protein synthesis, exhibiting bacteriostatic activity.
Uses of Terramycin
Terramycin is used in human medicine to treat various bacterial infections, including acne, chlamydia infections, mycoplasma infections, Haemophilus influenza, and rickettsial infections. It is also widely used in veterinary medicine and as a pesticide against bacterial diseases of crops.
Properties of Terramycin
The chemical formula of Terramycin is C22H24N2O9, with a molecular weight of 460.434 g/mol. It is a yellow crystal, soluble in water and slightly soluble in ethanol. The in vivo half-life is 6-8 hours.
Other Information on Terramycin
1. Terramycin Efficacy
Terramycin has a broad antibacterial spectrum, effective against gram-positive and gram-negative bacteria, Chlamydia, and Mycoplasma, although some bacteria may develop resistance.
2. Terramycin Side Effects
Topical application may cause itching and swelling. Internal use can lead to gastrointestinal symptoms, photosensitivity, and, rarely, damage to high-calcium organs like teeth and bones.
3. Tetracycline Antibiotics Other Than Terramycin
Similar natural tetracycline antibiotics include tetracycline and chlortetracycline. Chlortetracycline differs from tetracycline by the substitution of a chlorine atom.
4. Substances Related to Terramycin
Terramycin is prescribed for 6-8 weeks for moderate to severe acne, but alternative treatments should be considered if there is no improvement after 3 months. It is also effective against clostridial and spirochete infections and can be used for patients allergic to penicillins or macrolides. Doxycycline, with improved pharmacological properties, is often chosen for treating various infections.