What Is a Calibration Column?
A calibration column is a crucial device employed in analytical methodologies such as liquid chromatography and gas chromatography.
It is essential for tuning the performance and optimizing separation conditions in analytical instruments to achieve precise results. This device facilitates the separation of compounds within a sample through the use of a specialized packing material contained within the column. This material interacts with the sample’s compounds, separating them by allowing different molecules to elute at varying rates based on their interactions.
Beyond separation, calibration columns are instrumental in the standardization and benchmarking of analytical outcomes. They provide a reference mixture of standard substances that aid in verifying and fine-tuning the accuracy and performance of analytical instruments.