What Is Phenothiazine?
Phenothiazine, with the chemical formula C12H9NS, is a heterocyclic compound characterized by two benzene rings fused to thiazine. Known also as “10H-Phenothiazine” or “dibenzothiazine,” it serves as the backbone for various derivatives with diverse applications.
Uses of Phenothiazine
Phenothiazines find use in various fields such as insecticides, treatment of urinary tract infections, polymerization inhibitors, antioxidants, dyes, and notably in antipsychotics like chlorpromazine and promethazine, which are effective in treating schizophrenia and other conditions.
Properties of Phenothiazine
This compound is a pale yellow crystalline powder at room temperature, with a melting point of 185.1℃ and boiling point of 371℃. It’s easily soluble in acetone, slightly in ethanol, and insoluble in water, exhibiting stability yet susceptible to oxidation and light exposure.
Types of Phenothiazines
Available as reagents in various quantities such as 25g, 500g, and 1kg, phenothiazine and its derivatives are crucial in research and development. It is necessary to comply with laws and regulations in its handling and storage.
Other Information on Phenothiazine
1. Synthesis of Phenothiazine
Synthesis involves melting diphenylamine with sulfur and a catalyst, producing hydrogen sulfide as a byproduct.
2. Chemical Reaction of Phenothiazine
Light exposure causes phenothiazine to oxidize and darken, leading to various oxidized products. It decomposes under heat or acidic conditions, releasing toxic substances.
3. Phenothiazine Derivatives
Derivatives include methylene blue and various antipsychotics like promazine, chlorpromazine, and promethazine, each having specific applications in medical treatments.
4. Regulatory Information on Phenothiazines
Noted risks include skin and respiratory irritation, potential damage to major organ systems, and high toxicity to aquatic life, necessitating careful handling per regulatory standards.