What Is HFIP?
HFIP (1,1,1,3,3,3-hexafluoro-2-propanol), also known as hexafluoroisopropyl alcohol, is an organic compound with the chemical formula C3H2F6O. It is a clear, colorless liquid at room temperature, with a molecular weight of 168.04, a melting point of -4°C, and a boiling point of 59°C.
Uses of HFIP
HFIP is primarily used as a solvent in organic synthesis and polymer processing as well as a synthetic raw material in pharmaceuticals and agrochemicals. It can dissolve polymers like polyamide, polyacrylonitrile, polyacetal, polyester, and polyketones, which are insoluble in many other solvents. HFIP is also used in biochemistry, particularly in liquid-phase peptide chemistry, and as a component in buffer solutions for ion-pair HPLC.
Properties of HFIP
1. Synthesis of HFIP
HFIP is synthesized mainly by hydride reduction of hexafluoroacetone or through catalytic hydrogenation.
2. Chemical Properties of HFIP
Characterized by strong intramolecular polarization, HFIP’s electron-withdrawing trifluoromethyl groups (-CF3) and electron-donating hydroxy group (-OH) enhance its ability to dissolve various substances. HFIP facilitates a range of chemical reactions, including Friedel-Crafts-type reactions and epoxidation reactions using hydrogen peroxide.
Types of HFIP
HFIP is sold primarily for research and development purposes in various volumes, ranging from small quantities (e.g., 10mL, 25g) to larger amounts (e.g., 500mL, 500g). It requires cold storage, typically at 25°C or lower.
Other Information on HFIP
Safety of HFIP
HFIP is a corrosive compound and may cause skin irritation, serious eye damage, respiratory tract damage, and potential reproductive harm. It necessitates the use of protective equipment and adequate ventilation during handling. The compound is stable under normal storage conditions, but it should be stored away from high temperatures and direct sunlight to avoid reactions with strong oxidizing agents. Hazardous decomposition products include carbon monoxide, carbon dioxide, and halides.