What Is a Magnetic Bead?
Magnetic beads are nano-sized particles with magnetic properties. They are used in the fields of food, biotechnology research, and medicine. This magnetic force can be used to separate and purify various substances easily. In addition, because a magnetic bead is moved using magnets, they have the advantage that they do not require mechanical movement and are easy to clean.
Many companies are involved in the development of magnetic beads, which come in a variety of types. Uniform shape, strong magnetic force, dispersion, and adsorption properties are required.
Uses for Magnetic Beads
Magnetic beads are used in a variety of fields. One example is the medical field. Magnetic beads can be used to separate and purify cells, microscopic bacteria, proteins, and nucleic acids. A typical application is immunoprecipitation. Primary antibodies are placed in a solution containing antigens. Next, magnetic beads to which proteins or secondary antibodies are attached are added to the solution. Finally, by applying a magnet from the outside, only the magnetic beads can be adsorbed on the wall surface. This allows for efficient and rapid separation.
Principle of Magnetic Beads
Magnetic beads are used in a variety of fields, taking advantage of their characteristics. Here, we will introduce their typical characteristics.
- Points Useful for Separation and Purification
The greatest feature of magnetic beads is that they can easily separate and purify proteins and nucleic acids. It is possible to attach specific functional groups to magnetic beads, allowing them to be quickly bound and removed. In addition, by using magnetism, only magnetic beads can be removed, making it possible to purify samples with high concentrations. - Efficient Cleaning Points
By applying a magnet externally, only magnetic beads can be removed. In the cleaning process, the purified material is also washed away or impurities remain. However, by using magnetic beads, it is possible to take out the product in a highly concentrated state, thus reducing sample loss. Furthermore, since magnetic beads are removed using strong magnetic force, efficient cleaning is possible. Sufficient washing can be done in less time than general washing.