What Is Glucuronolactone?
Glucuronolactone is a white to light brown crystalline powder organic compound.
It is also known as D(+)-glucuronolactone, D-glucurono-3,6-lactone, glucurone, glucuronic acid lactone).
Glucuronolactone is not regulated by any of the major national laws and regulations.
Uses of Glucuronolactone
Glucuronolactone is mainly used in the pharmaceutical field, where it is useful in medicines for liver diseases, drinks to relieve fatigue, and drugs for acne and skin problems. In the human body, glucuronolactone acts on the liver and helps the liver function.
Glucuronolactone is converted to glucuronic acid by water in the human body. In the liver, glucuronic acid combines with waste materials that are unnecessary for humans to form glucuronide conjugates. The formation of the complex facilitates the elimination of waste substances from the body. This mechanism has the effect of increasing the liver’s detoxification capacity and blood flow.
In addition to improving the function of the liver, glucuronolactone also has an ameliorative effect on symptoms of hives, eczema, and pregnancy toxicity. These effects are not powerful, but they have few side effects.
Properties of Glucuronolactone
The chemical formula is C6H8O and the molecular weight is 176.12. The CAS number is 32449-92-6.
Its melting point is 170°C and it is solid at room temperature. It is an odorless compound, easily soluble in water and virtually insoluble in ethanol and acetic acid.
Types of Glucuronolactone
When dissolved in water, it yields an aqueous solution in which both of the compatible isomers, glucuronolactone and glucuronic acid, are present. It has been reported that both compatible isomers are present in vivo.
Other Information About Glucuronolactone
1. Production Method of Glucuronolactone
Glucuronolactone is obtained by oxidation and hydrolysis of trehalose in the presence of a metal catalyst. Another method for producing glucuronolactone is reported, in which glucose is converted to glucuronic acid through microbial fermentation, followed by lactonization to produce glucuronolactone.
2. Handling and Storage Precautions
Handling Precautions
Avoid contact with strong oxidizing agents. It should be used in a draft chamber with local exhaust ventilation. Also, wear personal protective equipment when using.
In Case of Fire
Combustion decomposition may produce irritating and toxic gases and vapors. Use water spray, foam, powder extinguisher, carbon dioxide gas, or extinguishing sand to extinguish fires.
In Case of Skin Contact
Be careful not to get it on your skin. Always wear protective clothing such as a lab coat or work clothes and protective gloves when using the product. Never roll up the sleeves of protective clothing to avoid skin exposure.
In the event of skin contact, wash off with soap and plenty of water. If on clothing, remove all contaminated clothing and isolate. If symptoms persist, seek medical attention.
In Case of Eye Contact
Always wear protective glasses or goggles when using the product. In the unlikely event of eye contact, rinse cautiously with water for several minutes.
If wearing contacts, remove them if they can be easily removed and rinse thoroughly. Seek immediate medical attention.
Storage
When storing, place it in a glass container, sealed with an inert gas. Store locked up in a cool, well-ventilated place away from direct sunlight.